Qihuang Zhuyu formula modulates mitochondrial function to inhibit platelet activation via endocannabinoid signaling mediated by the SIRT1/PPARα pathway
SIRT1 may mediate endocannabinoid signaling through its interaction with PPARα, regulating mitochondrial function and subsequently influencing platelet activation. QHZYF effectively modulates the endocannabinoid system via the SIRT1/PPARα pathway, thereby inhibiting platelet activation.
Authors
- Ning Yang (ORCID: https://orcid.org/0000-0002-4001-6168)
- Yun Yao
- Ruijie Shi
- Xiaohu CHEN
- Peng Yu (ORCID: https://orcid.org/0000-0002-3363-8911)
- Weixin Sun
- H Zhang
- Tong Sun (ORCID: https://orcid.org/0000-0003-3861-8933)
- Siyuan Yin (ORCID: https://orcid.org/0009-0007-1429-4547)
- KN Lai
Institutions
- Nanjing University of Chinese Medicine (CN)
- Nantong University (CN)
- Nanjing Traditional Chinese Medicine Hospital (CN)
- Jiangning District of Nanjing Chinese Medicine Hospital (CN)
- Yancheng First People's Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2024-11-03
- DOI
- https://doi.org/10.1016/j.jep.2024.119006
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00