High-intensity Interval Training Promotes Neural Remodeling Of Adipose Tissue In Nutritionally Obese Mice

PURPOSE: In an obese state, white adipose tissue is unable to maintain appropriate nerve innervation and undergoes a process of neurodegeneration, resulting in a decrease in nerve processes. Exercise has been proven to promote neuronal remodeling, promote neuronal growth, lower blood lipids, and reduce weight. based on this, this study provides theoretical support for promoting adipose nerve remodeling, restoring benign control of adipose tissue, and restoring a healthy microenvironment of adipose tissue through exercise. METHODS: In this study, a model was established by feeding high-fat diet, and the nutritional obese mice were subjected to aerobic exercise intervention for 8 weeks, and they were divided into normal control group (NC), obese control group (OC), high-fat moderate-intensity training group (HF-Mid), and high-fat high-intensity interval training group (HF-HIIT). RESULTS: Compared with the NC group, the OC group had body weight, body fat percentage, serum TC, TG, LDL-C,IL-6, TNF-α,Leptin significantly increased (P < 0.01), while HDL-C decreased (P < 0.01). In liver oil red O staining, there was a significant increase in orange red lipid droplets (P < 0.05). Immunofluorescence staining localization showed a decrease in tyrosine hydroxylase (TH) expression in adipose tissue (P < 0.05).Compared with the OC group, the HF-HIIT group had body weight, body fat percentage, serum TC, TG, LDL-C,IL-6, TNF-α,Leptin significantly decreased (P < 0.01), while HDL-C significantly increased (P < 0.01). The orange red lipid droplets in liver oil red O staining were significantly reduced (P < 0.05). Immunofluorescence staining localization showed an increase in tyrosine hydroxylase (TH) expression in adipose tissue (P < 0.01). CONCLUSIONS: High intensity interval training brings significant lipid-lowering and weight-loss effects, and restores the dominance of adipose tissue neurons in obese individuals, significantly increasing the occurrence of adipose neuron remodeling.