Optimizing Pharmaceutical Tablets: A Comprehensive Analysis of Hardness, Diameter and Thickness

Three crucial components of pharmaceutical tablet formulation—hardness, diameter, and thickness—are essential to achieving the best possible drug administration. This thorough investigation explores three essential elements of pharmaceutical tablet formulation—hardness, diameter, and thickness—in the quest for ideal medication delivery. By analyzing seminal studies over the last twenty years, we pinpoint important knowledge gaps and provide a path forward for future study. We demonstrate the complex relationship between lubricants and tablet hardness through a thorough analysis considering methodologies, results, and consequences. Our results highlight the post-compression parameters' critical roley in preserving consistent quality and offering insightful information to regulators, producers, and academics. This review fosters prospects for pharmaceutical tablet formulation and quality assurance breakthroughs by capturing current knowledge on the subject and outlining options for further exploration.