An increase of the oncogenesis frequency is associated with the DAMPs accumulation and the killer cell subpopulations ratio change in patients with long-term post-COVID-19 syndrome

In patients with malignant lesions of the lungs and pancreas, the development of which was facilitated by the long-term post-COVID-19 syndrome (PCS), presence a significant increase (on average by 80%) in the serum content of the cytotoxic oligonucleotide fraction DAMP was found. High antigenic load due to the increase of DAMP contributed to the absorptive function growth and insufficient digestive function of neutrophils; decrease in the NADPH-catalase activity reserve in oxygen-dependent phagocytosis. An increase of CD16+ NK cells of innate immunity and an overexpression of CD8+ killer/suppressor T lymphocyte receptors of adaptive immunity in response to the suppressor coreceptors competitive action were revealed. These changes in cellular immunity were more pronounced in patients with malignant lung lesions and correlated with low serum conductivity. To predict the individual course of the disease, it is advisable to carry out screening measurements of electrical conductivity of blood serum and to determine the control points of innate and adaptive immunity changes in patients with comorbid pathology: PCS and an oncological process. In further studies, attention should be paid to the algorithm development of immunological and screening tests for the oncological diseases course prognosis and the treatment tactics effectiveness.