Insights Into Resection for Esophageal Adenocarcinoma.

e d G I D i s o r d e r s G&H Could you briefly summarize the association between esophageal adenocarcinoma and gastroesophageal reflux disease?DP Acid reflux can be either symptomatic or asymptomatic; however, in either event, it can lead to inflammatory changes typically in the distal esophagus and at the gastroesophageal junction.In some patients, acid reflux can lead to metaplasia, specifically intestinal metaplasia, which when present in the distal esophagus or gastroesophageal junction is known as Barrett esophagus (BE).Although most often nondysplastic, BE is the only identified histologic precursor to dysplasia or premalignant change that can lead to higher degrees of dysplasia and, in a subset of patients, to esophageal adenocarcinoma (EAC).G&H What is the next step after EAC is detected?