Effectiveness of the autumn 2023 COVID-19 vaccine dose in hospital-based healthcare workers: results of the VEBIS healthcare worker vaccine effectiveness cohort study, seven European countries, season 2023/24
COVID-19 vaccination recommendations include healthcare workers (HCWs). We measured COVID-19 vaccine effectiveness (CVE) of the autumn 2023 dose against laboratory-confirmed SARS-CoV-2 infection in a prospective cohort study of 1,305 HCWs from 13 European hospitals. Overall CVE was 22% (95% CI: -17 to 48), 49% (95% CI: -8 to 76) before and -11% (95% CI: -84 to 34) after the start of BA.2.86/JN.1 predominant circulation. Autumn 2023 COVID-19 vaccination led to a moderate-to-low reduction in SARS-CoV-2 infection incidence in HCWs. Monitoring of CVE is crucial for COVID-19 prevention.
Authors
- Elza Barzdina
- Albert Prats‐Uribe (ORCID: https://orcid.org/0000-0003-1202-9153)
- Mihaela Lazăr (ORCID: https://orcid.org/0000-0002-8226-6026)
- Lauren Ferguson (ORCID: https://orcid.org/0000-0002-8506-9888)
- Jonathan McGrath (ORCID: https://orcid.org/0000-0001-8227-0976)
- Anneli Uusküla (ORCID: https://orcid.org/0000-0002-4036-3856)
- Alma Kosa
- Rosaria Santangelo (ORCID: https://orcid.org/0000-0002-8056-218X)
- Claire Kenny
- Miriam Latorre-Millán (ORCID: https://orcid.org/0000-0001-9932-0124)
- Dace Zavadska (ORCID: https://orcid.org/0000-0003-4892-3763)
- Kim Brolin
- Corneliu Petru Popescu (ORCID: https://orcid.org/0000-0001-6316-0333)
- Rita Murri (ORCID: https://orcid.org/0000-0001-9468-5458)
- Camelia Savulescu (ORCID: https://orcid.org/0000-0002-5374-835X)
- Cristiane A. Henriques (ORCID: https://orcid.org/0000-0003-4738-2344)
- Dagne Grãvele
- Sabrina Bacci (ORCID: https://orcid.org/0000-0002-6575-3439)
- Catherine Fleming (ORCID: https://orcid.org/0000-0002-9630-1064)
- Dainis Krieviņš (ORCID: https://orcid.org/0000-0003-1570-5532)
- Vânia Gaio (ORCID: https://orcid.org/0000-0001-7626-4991)
- Anthony Nardone (ORCID: https://orcid.org/0000-0003-1138-0937)
- Carmen Muñoz‐Almagro (ORCID: https://orcid.org/0000-0001-5586-404X)
- Ana Milagro (ORCID: https://orcid.org/0000-0002-3888-8952)
- Colm J Bergin (ORCID: https://orcid.org/0000-0002-6651-1132)
- Viesturs Zvirbulis
- Pilar Subirats
- Ilze Āboliņa
- Laura Clusa (ORCID: https://orcid.org/0000-0002-3503-2331)
- Raluca Hrișcă
- Jacklyn Sui
- Simin Aysel Florescu (ORCID: https://orcid.org/0000-0002-6482-3386)
- Ausenda Machado
- Săftica-Mariana Pohrib
- Miguel Cisneros (ORCID: https://orcid.org/0009-0001-9715-887X)
- Katleen de Gaetano Donati
- Liis Lohur
Institutions
- Università Cattolica del Sacro Cuore (IT)
- Hospital Sant Joan de Déu Barcelona (ES)
- Carol Davila University of Medicine and Pharmacy (RO)
- Vibhavadi Hospital (TH)
- Agostino Gemelli University Polyclinic (IT)
- University Hospital Galway (IE)
- Universitat Internacional de Catalunya (ES)
- Pauls Stradiņš Clinical University Hospital (LV)
- Collaborative Research Group (AU)
- Hospital Universitario Miguel Servet (ES)
- Children's Clinical University Hospital (LV)
- Zero to Three (US)
- Spitalul Clinic Dr. Victor Babes (RO)
- Instituto de Investigación Sanitaria Aragón (ES)
- National Institute of Health Dr. Ricardo Jorge (PT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- St. James's Hospital (IE)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (ES)
- University of Tartu (EE)
- European Centre for Disease Prevention and Control (SE)
Publication Details
- Journal
- Eurosurveillance
- Published
- 2024-10-31
- DOI
- https://doi.org/10.2807/1560-7917.es.2024.29.44.2400680
- Citations
- 5
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 1.95
Funders
- European Centre for Disease Prevention and Control