Targeting Long Noncoding <scp>RNA H19</scp> in Subchondral Bone Osteocytes and the Alleviation of Cartilage Degradation in Osteoarthritis
In summary, our results provide new evidence that the elevated H19 expression in osteocytes may contribute to aberrant subchondral bone remodeling and OA progression. H19 appears to be required for the osteocyte response to mechanical stimulation, and targeting H19 represents a new promising approach for OA treatment.
Authors
- Zhe Zhang (ORCID: https://orcid.org/0000-0002-7904-019X)
- Shuai Deng (ORCID: https://orcid.org/0000-0001-7622-2097)
- Babak Mehrjou (ORCID: https://orcid.org/0000-0003-3493-6598)
- Chuanhai Liu (ORCID: https://orcid.org/0000-0003-1919-7280)
- Michael Tim‐Yun Ong (ORCID: https://orcid.org/0000-0002-4460-9286)
- Belle Yu Hsuan Wang
- Rongliang Wang (ORCID: https://orcid.org/0000-0003-0608-819X)
- Hon Fai Chan (ORCID: https://orcid.org/0000-0003-0573-1251)
- Wayne Lee (ORCID: https://orcid.org/0000-0002-0486-360X)
- Paul Kim-Ho Chu (ORCID: https://orcid.org/0000-0002-5581-4883)
- Jack C. Y. Cheng (ORCID: https://orcid.org/0000-0001-8153-364X)
- Dan Li (ORCID: https://orcid.org/0000-0003-1975-3785)
- Haixing Wang (ORCID: https://orcid.org/0000-0001-8555-4827)
- Qiangqiang Li (ORCID: https://orcid.org/0000-0001-5556-2586)
- Xiaomin Lu
- Yanlun Zhu
- Dorsa Dehghan‐Banian
Institutions
- City University of Hong Kong (HK)
- Chinese University of Hong Kong (HK)
- Chinese Academy of Sciences (CN)
- Hong Kong Science and Technology Parks Corporation (HK)
- Nanjing Drum Tower Hospital (CN)
- Prince of Wales Hospital (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2024-10-31
- DOI
- https://doi.org/10.1002/art.43028
- Citations
- 13
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 3.71
Funders
- Hong Kong Polytechnic University
- Chinese University of Hong Kong