Investigation of the acute effect of the synthetic hemodialysis membrane on the expression of <i>XRCC1</i> and <i>PARP1</i> in chronic hemodialysis patients
Although our study findings indicate that HD membranes do not affect gene expression overall, the specific decrease in PARPI gene expression suggests that the effectiveness of the BER DNA repair mechanism is impaired in ESRD patients, which may play a significant role in the progression of the disease.
Authors
- Mehmet Rıza Altıparmak
- Selin Unal
- Serkan Feyyaz Yalın (ORCID: https://orcid.org/0000-0002-8146-6966)
- Bahadır Batar (ORCID: https://orcid.org/0000-0001-8760-8411)
- Mehmet Güven (ORCID: https://orcid.org/0000-0002-8749-1708)
Institutions
- Tekirdağ Namık Kemal University (TR)
- Dr Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi (TR)
- Istanbul University-Cerrahpaşa (TR)
Publication Details
- Journal
- The International Journal of Artificial Organs
- Published
- 2024-10-31
- DOI
- https://doi.org/10.1177/03913988241288379
- Primary Topic
- PARP inhibition in cancer therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00