AIMP1-Derived Peptide Secreted from Hair Follicle Stem Cells Promotes Hair Growth by Activating Dermal Papilla Cells
Hair follicle stem cells (HFSCs) and dermal papilla cells (DPCs) are crucial in the biogenesis and maintenance of hair follicles (HFs). This study demonstrated that a fragment derived from aminoacyl-tRNA synthetase-interacting multifunctional protein1 (AIMP1) secreted from HFSCs activated DPCs and maintained HF homeostasis. A histological analysis revealed that AIMP1 levels in HF decreased with hair loss. Hair regrowth in AIMP1-induced mice was faster than in non-induced mice. Deletion mapping revealed 41 amino acids (TN41, aa 6-46) as the active region of AIMP1. The N-terminal peptide fragment of AIMP1 generated by MMP1 was secreted from Wnt-treated HFSCs to activate DPCs. TN41 activated Akt and ERK, increased β-catenin, and enhanced DPC activation. TN41 promoted hair shaft elongation in cultured human HFs and improved the hair-inducing activity of cultured DPC spheroids. Our findings suggest that the AIMP1 fragment secreted from HFSCs stimulates active hair regrowth through activating DPCs.
Authors
- Min‐Chul Park (ORCID: https://orcid.org/0000-0002-8575-085X)
- Young Kwan Sung (ORCID: https://orcid.org/0000-0002-5122-4616)
- Soon Sun Bak
- Soohwan Oh (ORCID: https://orcid.org/0000-0003-4860-034X)
- Doyeun Kim
- Seung Jae Jeong (ORCID: https://orcid.org/0000-0001-5659-9225)
- Ina Yoon (ORCID: https://orcid.org/0000-0001-5307-3754)
- Sang Bum Kim (ORCID: https://orcid.org/0000-0002-0105-5885)
- YounHa Kim
- Jihee Kim
- Sung‐Hoon Kim (ORCID: https://orcid.org/0000-0002-1570-3230)
- Jina Kim (ORCID: https://orcid.org/0000-0003-1684-4219)
- Ho Lee (ORCID: https://orcid.org/0000-0001-5573-742X)
- Seongmin Cho (ORCID: https://orcid.org/0000-0003-1834-8972)
- Yoon Jeon
- Khas-Erdene Battogtokh
Institutions
- Inje University (KR)
- Yonsei University (KR)
- Korea University (KR)
- Sahmyook University (KR)
- Kyungpook National University (KR)
- National Cancer Center (US)
- National Cancer Center (KR)
- Gangnam Severance Hospital (KR)
- Io Therapeutics (United States) (US)
Publication Details
- Journal
- International Journal of Biological Sciences
- Published
- 2024-10-21
- DOI
- https://doi.org/10.7150/ijbs.101127
- Citations
- 5
- Primary Topic
- Hair Growth and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.68
Funders
- National Research Foundation
- Yonsei University
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea