LCM-RNAseq Highlights Intratumor Heterogeneity and a lncRNA Signature from Archival Tissues of GH-Secreting PitNETs
This study demonstrates the potential of LCM-RNAseq to unlock hidden molecular diversity within archived pituitary tumor samples. By focusing on specific cell populations, we identified lncRNAs expressed at different levels within the tumors, potentially offering new insights into the complex biology of GH-secreting PitNETs. This evidence prompts further research into the role of lncRNAs in pituitary neuroendocrine tumor aggressiveness and personalized treatment strategies.
Authors
- Angela Carlino (ORCID: https://orcid.org/0000-0003-4827-357X)
- Antonella Farsetti (ORCID: https://orcid.org/0000-0002-8603-7925)
- Simona Nanni (ORCID: https://orcid.org/0000-0002-3320-1584)
- Claudio Sette (ORCID: https://orcid.org/0000-0003-2864-8266)
- Guido Rindi (ORCID: https://orcid.org/0000-0003-2996-4404)
- Luciano Giacò (ORCID: https://orcid.org/0000-0003-0657-4323)
- Claudio Grassi (ORCID: https://orcid.org/0000-0001-7253-1685)
- Luca Cis
- Davide Bonvissuto (ORCID: https://orcid.org/0009-0003-2158-3110)
- Marco Gessi (ORCID: https://orcid.org/0000-0002-0461-1445)
- Sara De Martino (ORCID: https://orcid.org/0000-0002-6226-4090)
- Carlo Gaetano (ORCID: https://orcid.org/0000-0002-5238-1832)
- Alfredo Pontecorvi (ORCID: https://orcid.org/0000-0003-0570-6865)
- Valeria Pecci (ORCID: https://orcid.org/0000-0001-9170-3593)
- Antonio Bianchi (ORCID: https://orcid.org/0000-0002-4896-5499)
Institutions
- Università Cattolica del Sacro Cuore (IT)
- Agostino Gemelli University Polyclinic (IT)
- Istituti Clinici Scientifici Maugeri (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- National Research Council (IT)
- Istituto di Analisi dei Sistemi ed Informatica Antonio Ruberti (IT)
Publication Details
- Journal
- Genes
- Published
- 2024-10-31
- DOI
- https://doi.org/10.3390/genes15111426
- Citations
- 2
- Primary Topic
- Growth Hormone and Insulin-like Growth Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.72
Funders
- Ministero della Salute