Selection of the base for a topical pharmaceutical form for stump care after prosthetic fitting

The aim of the work. Rehabilitation of patients with amputation of the lower limbs is an urgent task of society. Currently, the pharmaceutical market of Ukraine lacks medicinal products for stump care of domestic production. Therefore, the aim of this work was to research the selection of the basis of soft medicine for the care of stumps after prosthetics. Materials and methods. The objects of the study were samples of a soft medicinal product on an emulsion basis. Gelling agents (aristoflex, xanthan gum, aerosil) were used as regulators of the structural and mechanical parameters of soft medicine. Research was conducted using a set of studies to determine organoleptic and structural-mechanical indicators. Results. According to the results of the organoleptic analysis, according to the indicators of homogeneity, the presence of delamination, samples were selected for further research, where aristoflex and xanthan gum were used as a thickener. According to the results of structural and mechanical studies, it was established that the samples with xanthan gum have a satisfactory degree of spreading and adhesiveness, which increases with increasing exposure to mechanical forces. The determined values ​​of static and dynamic coefficients of friction testify to the sliding properties of samples with xanthan gum. Conclusion. It was established that the addition of xanthan gum to the composition of the base would provide all the necessary characteristics for a soft medicine that is planned to be used in the care of the stump after prosthetics