Comparative study of the adsorption activity of enterosorbents by spectrophotometric method

At the present stage in practice enterosorbents are used, which differ in dosage form, chemical structure, selectivity and mechanisms of action. When choosing an enterosorbent to include it in the complex therapy it is necessary to take into account the presence of high adsorption activity (AA) of the drug. Objective. To compare AA of sorbents under conditions close to physiological ones. Materials and methods. The AA of medical sorbents (Alesorb®) in the form of ALESORB® “Enterosorbent” powder and Polysorb® powder; ALESORB® “Enterosorbent Gel” ERCIG without flavourings and Enterosgel® paste was studied by spectrophotometric method using methyl orange and gelatin as adsorption markers at pH=2.0 and pH=7.5, simulating the environment of the stomach and duodenum. Results. The obtained data indicate that the level of AA of sorbing agent (Alesorb®) in the form of ALESORB® “Enterosorbent” powder and ALESORB® “Enterosorbent Gel” ERCIG without flavourings with respect to the used marker substances, are superior to Polysorb® powder and Enterosgel® paste. The obtained results give a reason to consider sorbing agents (Alesorb®) in the form of ALESORB® “Enterosorbent” powder and ALESORB® “Enterosorbent Gel” ERCIG without flavourings as effective and priority means for prevention and treatment of diseases, in the therapy of which enterosorption is envisaged.