[Establishment of BCL-2 Inhibitors-Resistant B-cell Acute Lymphoblastic Leukemia Cell Lines and Study on Their Resistance Mechanisms].
Drug-resistant B-ALL cell lines could be successfully established by exposing RS4;11 cell line to the ascending concentration of BCL-2 inhibitors, and the drug resistance mechanism may be related to the overexpression of EP300.
Authors
- Yingchi Zhang (ORCID: https://orcid.org/0000-0003-1429-0152)
- Xiaofan Zhu (ORCID: https://orcid.org/0000-0002-2572-6495)
- Yixuan Wu (ORCID: https://orcid.org/0000-0003-2541-5133)
- Yuli Cai (ORCID: https://orcid.org/0000-0003-3149-1167)
- Jingliao Zhang (ORCID: https://orcid.org/0000-0003-2962-9884)
- Yong-Juan Duan
- Xuan Wei (ORCID: https://orcid.org/0000-0002-3726-2253)
Institutions
- Tianjin University of Sport (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Tianjin Economic-Technological Development Area (CN)
- Institute of Hematology & Blood Diseases Hospital (CN)
Publication Details
- Journal
- PubMed
- Published
- 2024-10-01
- DOI
- https://doi.org/10.19746/j.cnki.issn.1009-2137.2024.05.001
- Primary Topic
- Chronic Lymphocytic Leukemia Research
- Type
- article