[Chidamide Combined with (+) -JQ-1 to Kill <i>MLL</i>-Rearrangement Acute Myeloid Leukemia Cells by Disrupting the DNA Damage Response Pathway].
Chidamide combined with (+)-JQ-1 can inhibit the proliferation of <i>MLL</i>-r AML cells, inhibit the initiation of protective self-repair of these leukemia cells by inhibiting the DNA damage response pathway, and ultimately increase the apoptosis of these cells, but non- <i>MLL</i>-r AML cells have no similar results.
Authors
- M Ma (ORCID: https://orcid.org/0000-0002-3529-0330)
- Zhihua Zhang (ORCID: https://orcid.org/0000-0003-1583-9311)
- Rong‐Juan Zhang
- Qingming Zhang (ORCID: https://orcid.org/0000-0002-3862-0518)
- Lihong Wang (ORCID: https://orcid.org/0000-0002-2938-8892)
- Wei Wang (ORCID: https://orcid.org/0009-0006-4755-1194)
- Fengmei Li (ORCID: https://orcid.org/0000-0001-7077-1204)
Institutions
- Chengde Medical University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2024-10-01
- DOI
- https://doi.org/10.19746/j.cnki.issn.1009-2137.2024.05.004
- Primary Topic
- Cancer Treatment and Pharmacology
- Type
- article