[Effects of Down-Regulation of <i>PAK1</i> on Differentiation and Apoptosis of MPN Cells with <i>MPLW515L</i> Gene Mutation and Survival of 6133/MPL Mice].
Down-regulation of <i>PAK1</i> can significantly inhibit the growth of 6133/MPL cells, promote the formation of polyploid DNA, induce 6133/MPL cell apoptosis, and prolong the survival time of 6133/MPL mice.
Authors
- Qi-Gang Zhang
- Chunling Fu
- Liwei Zhang (ORCID: https://orcid.org/0000-0002-9247-6334)
- Kailin Xu (ORCID: https://orcid.org/0000-0003-1375-1084)
- Shujin Wang (ORCID: https://orcid.org/0000-0003-2485-9023)
- Xiangru Yu
Institutions
- Xuzhou Medical College (CN)
Publication Details
- Journal
- PubMed
- Published
- 2024-10-01
- DOI
- https://doi.org/10.19746/j.cnki.issn.1009-2137.2024.05.026
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article