Fortifying SNEDDS with Hybrid Technologies: Present and Future Prospects

Self-nano-emulsifying drug delivery systems (SNEDDS) have gained attention in recentyears as an effective approach for improving the solubility and oral bioavailability of poorlywater-soluble drugs. However, there have been reports of drawbacks such as low drug loading,limited stability and variability in absorption. Various technologies have been investigated in conjunctionwith SNEDDS to alleviate such issues such as polymers being used to improve stabilityand drug loading; phospholipid complexes used to improve absorption and reduce inter and intrasubjectvariability; SNEDDS for drug targeting improves the targeting of drugs to specific site reducingthe dosage required for action. 3D printing is used to create personalized and precisedosages; supersaturated SNEDDS is used to increase drug concentration; and solid SNEDDS areused to improve storage stability and patient compliance. The amalgamation of SNEDDS with thesetechnologies has demonstrated promising results with regard to the improvement of medicationdelivery and has control over SNEDDS limitations. The present review elucidates the applicationof blended technologies with SNEDDS and the future potential for such drug delivery.