Mendelian randomization study on the causal relationship between chronic hepatitis B/C virus infection and idiopathic pulmonary fibrosis

This study, using the bidirectional MR, provides preliminary evidence that chronic HBV and HCV infections are not causally related to IPF at the genetic level. However, this conclusion requires support from larger sample sizes in genome-wide association study (GWAS) databases for further MR analysis, and additional clinical studies and animal experiments are needed for validation.

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Publication Details

Journal
Journal of Thoracic Disease
Published
2024-10-01
DOI
https://doi.org/10.21037/jtd-24-392
Primary Topic
Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Type
article
Field-Weighted Citation Impact
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article

Mendelian randomization study on the causal relationship between chronic hepatitis B/C virus infection and idiopathic pulmonary fibrosis

Jun Guo, Huaiqing Qi
Journal of Thoracic Disease
Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
article

Mendelian randomization study on the causal relationship between chronic hepatitis B/C virus infection and idiopathic pulmonary fibrosis

Jun Guo, Huaiqing Qi
article en

Abstract

This study, using the bidirectional MR, provides preliminary evidence that chronic HBV and HCV infections are not causally related to IPF at the genetic level. However, this conclusion requires support from larger sample sizes in genome-wide association study (GWAS) databases for further MR analysis, and additional clinical studies and animal experiments are needed for validation.

Journal of Thoracic DiseaseVol. 16(10)
Beijing Tsinghua Chang Gung Hospital (CN), Tsinghua University (CN)
Good health and well-being
Openalex Percentile: Top 64%
Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
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