Ameliorating lipopolysaccharide induced acute lung injury with Lianhua Qingke: focus on pulmonary endothelial barrier protection
In summary, LHQK can mitigate LPS-induced inflammatory infiltration, pulmonary edema, and pulmonary vascular endothelial barrier dysfunction in the context of ALI/ARDS. This is achieved by decreasing the levels of VCAM-1, and increasing the expression levels of barrier-associated junctions, such as VE-cadherin and occludin. Consequently, LHQK exhibits promising therapeutic potential in preventing the progression of ALI/ARDS.
Authors
- Peipei Jin (ORCID: https://orcid.org/0000-0002-5787-1777)
- Zhenhua Jia
- Zhonglei He (ORCID: https://orcid.org/0000-0001-6533-4974)
- Ningxin Han (ORCID: https://orcid.org/0000-0001-8082-690X)
- Tongxing Wang (ORCID: https://orcid.org/0000-0002-4008-7230)
- Yuanjie Hao
- Yunlong Hou (ORCID: https://orcid.org/0000-0002-6989-8221)
- Xiaoqi Wang (ORCID: https://orcid.org/0000-0003-4478-9245)
- Wei Feng (ORCID: https://orcid.org/0000-0002-8610-7372)
- Yu Han (ORCID: https://orcid.org/0000-0001-5983-3873)
- Yujie Yin (ORCID: https://orcid.org/0000-0002-9878-5568)
- Hui Qi (ORCID: https://orcid.org/0000-0002-5695-9662)
- Jing Guo (ORCID: https://orcid.org/0000-0003-2463-3630)
- Jiemeng Sun
- Yi Liu (ORCID: https://orcid.org/0009-0000-9088-576X)
- Yan Ma (ORCID: https://orcid.org/0009-0008-0887-1261)
Institutions
- Hebei Medical University (CN)
- Hebei Yiling Hospital (CN)
- Hebei University of Chinese Medicine (CN)
- Hebei Academy of Sciences (CN)
- State Key Laboratory for Innovation and Transformation of Luobing Theory
Publication Details
- Journal
- Journal of Thoracic Disease
- Published
- 2024-10-01
- DOI
- https://doi.org/10.21037/jtd-24-700
- Citations
- 2
- Primary Topic
- Plant-based Medicinal Research
- Type
- article
- Field-Weighted Citation Impact
- 0.93
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hebei Province