Single-cell RNA sequencing analysis reveals the role of TXNDC5 in keloid formation
Our study indicated that TGF-β signaling pathway was enriched in fibroblast cells, and TXNDC5 was positively correlated with proliferation, migration, and TGF-β signaling pathway. Cellular experiment demonstrated that knocking down TXNDC5 downregulated TGF-β1 expression, and suppressed migration and invasion of KFs. The current discoveries provided a new therapeutic strategy for the treatment of keloid.
Authors
- Hongju Xie
- Lining Xian
- Shudan Zheng (ORCID: https://orcid.org/0009-0006-9330-3941)
- Jianmin Li (ORCID: https://orcid.org/0000-0002-2225-5317)
- Zhikun Liu (ORCID: https://orcid.org/0000-0002-2327-6195)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- First Affiliated Hospital of Guangzhou University of Chinese Medicine (CN)
- Hainan Medical University (CN)
Publication Details
- Journal
- CytoJournal
- Published
- 2024-10-31
- DOI
- https://doi.org/10.25259/cytojournal_58_2024
- Citations
- 2
- Primary Topic
- Dermatologic Treatments and Research
- Type
- article
- Field-Weighted Citation Impact
- 1.07