Possible involvement of Toll-like receptor 8-positive monocytes/macrophages in the pathogenesis of Sjögren’s disease
These results suggest that infiltrating monocytes and macrophages may produce cytokines and chemokines through TLR8 stimulation, potentially enhancing B7 molecule expression, promoting the adaptive immune response, and contributing to SjD pathogenesis.
Authors
- Haruki Nagano
- Yuka Miyahara
- Tomoki Sueyoshi
- Naoki Kaneko (ORCID: https://orcid.org/0000-0002-3579-7908)
- Shiho Yokomizo
- M. Sakamoto (ORCID: https://orcid.org/0000-0003-2999-5681)
- Lijing L. Yan (ORCID: https://orcid.org/0000-0002-3029-0462)
- Hiromu Kido
- Junsei Sameshima (ORCID: https://orcid.org/0009-0009-7391-4771)
- Seiji Nakamura (ORCID: https://orcid.org/0009-0005-7623-7287)
- Masafumi Moriyama (ORCID: https://orcid.org/0000-0003-2911-2244)
- Chen Hu (ORCID: https://orcid.org/0000-0001-6826-9637)
- Yukiko Ohyama
- Shintaro Kawano
Institutions
- Kyushu University (JP)
- Kyushu Dental University (JP)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-10-31
- DOI
- https://doi.org/10.3389/fimmu.2024.1480675
- Citations
- 4
- Primary Topic
- Salivary Gland Disorders and Functions
- Type
- article
- Field-Weighted Citation Impact
- 1.31
Funders
- Takeda Science Foundation
- Uehara Memorial Foundation
- Heiwa Nakajima Foundation
- Japan Society for the Promotion of Science
- Japan Science and Technology Agency