The microglial innate immune receptor TREM2 participates in fear memory formation through excessive prelimbic cortical synaptic pruning
Our cumulative results suggest that prelimbic TREM2-mediated excessive microglial synaptic pruning is involved in the fear memory formation process, leading to development of abnormal stress-related behavior.
Authors
- Yajing Chu (ORCID: https://orcid.org/0000-0001-6239-1519)
- Cheng Peng (ORCID: https://orcid.org/0000-0001-5043-6425)
- Lele Zhang (ORCID: https://orcid.org/0000-0002-5595-3103)
- Yongmei Zhang (ORCID: https://orcid.org/0000-0002-0919-904X)
- Rong Hua (ORCID: https://orcid.org/0000-0003-2829-0882)
- Zi-ming Zhou
Institutions
- Xuzhou Medical College (CN)
- National Medical Products Administration (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-10-31
- DOI
- https://doi.org/10.3389/fimmu.2024.1412699
- Citations
- 5
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.24