Dexamethasone and IFN-γ primed mesenchymal stem cells conditioned media immunomodulates aberrant NETosis in SLE via PGE2 and IDO
Our study highlights the multifaceted impact of IW and DW on NETosis, ROS dynamics, and lupus severity in SLE. These findings underscore the potential of preconditioned media for the development of targeted, personalized approaches for SLE treatment.
Authors
- Manaswi Chaubey
- Sujata Mohanty (ORCID: https://orcid.org/0000-0002-0047-4914)
- Kiran Giri (ORCID: https://orcid.org/0000-0001-7866-6388)
- Hiral Thacker
- Geeta Rai (ORCID: https://orcid.org/0000-0001-8162-8964)
- Sonali Rawat (ORCID: https://orcid.org/0000-0001-6518-3547)
- Khushbu Priya
- Shambhavi Singh (ORCID: https://orcid.org/0000-0002-6961-2289)
- Madhukar Rai
Institutions
- Institute for Stem Cell Biology and Regenerative Medicine (IN)
- D.Y. Patil University (IN)
- Institute of Medical Sciences (IN)
- All India Institute of Medical Sciences (IN)
- Banaras Hindu University (IN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-10-31
- DOI
- https://doi.org/10.3389/fimmu.2024.1461841
- Citations
- 6
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.44
Funders
- Centers for Disease Control and Prevention