(Pro)renin receptor aggravates myocardial pyroptosis in diabetic cardiomyopathy through AMPK-NLRP3 pathway
PRR aggravated pyroptosis of cardiomyocyte, increased the dysfunction of cardiomyocyte, and may be related to the decrease of AMPK phosphorylation and the overactivation of NLRP3. This may provide new ideas and targets for the treatment of DCM.
Authors
- Haipeng Jie
- Bo Dong (ORCID: https://orcid.org/0000-0002-0918-5449)
- Yuewen Zhao (ORCID: https://orcid.org/0000-0002-8765-1839)
- Jingjing Zhang (ORCID: https://orcid.org/0000-0001-5122-0909)
- Kang Li (ORCID: https://orcid.org/0000-0002-9357-0373)
- Shengnan Li (ORCID: https://orcid.org/0000-0001-5469-937X)
Institutions
- Shandong University (CN)
- University of Dundee (GB)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Shandong Provincial Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-10-31
- DOI
- https://doi.org/10.3389/fphar.2024.1453647
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China