Glycolysis regulated exosomal LINC01214 inhibited CD8+ T cell function and induced anti-PD1 resistance in melanoma via modulating miR-4492/PPP1R11 axis
Our results demonstrated that exosomal LINC01214 released by melanoma cells promoted immunotherapy resistance by inducing CD8<sup>+</sup> T cell dysfunction via the miR-4492/PPP1R11 regulatory loop. Targeting cirLINC01214 might be a potential therapeutic strategy to enhance the outcome of immunotherapy in melanoma.
Authors
- Jie Qiao (ORCID: https://orcid.org/0000-0003-2126-1376)
- Daohe Wang
- Jun‐Yi Yang (ORCID: https://orcid.org/0000-0002-6332-6265)
- Fanli Guo
- Baojin Wu
- Zhi Ding
Institutions
- Fudan University (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- Non-coding RNA Research
- Published
- 2024-10-31
- DOI
- https://doi.org/10.1016/j.ncrna.2024.10.005
- Citations
- 8
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 1.87