Effect of Trichosanthis Radix Extract on Anti-allergy and Skin Inflammation

This study was conducted to study the effects of TR-W and TR-E on anti-allergy and skin inflammation inhibition. In order to check the concentration used in the experiment and its toxicity to cells, RBL-2H3 cells and HMC-1 cells were treated with TR-W and TR-E at different concentrations and tested at a concentration of 100 mg/ml or less, which does not affect the survival rate. proceeded. In order to determine the effect on the inflammatory response to mast cells, the inflammatory cytokines TNF-α, IL-8, and IL-6 were measured. As a result, TR-W and TR were found in TNF-α and IL-8, which promote the early inflammatory response. -E showed a significant effect at 100 mg/ml, and TR-E showed a significant effect at 50 mg/ml, showing the effect even at a lower concentration than TR-W. IL-6, which is involved in causing allergic dermatitis, showed a significant effect at 100 and 50 mg/ml in TR-W and TRE, indicating that it is effective in suppressing inflammation in TR-W and TR-E. In addition, histamine and β-hexosaminidase, which are inflammatory mediators involved in the initial allergic reaction, were significantly suppressed at 100 and 50 mg/ml in TR-W and TR-E, demonstrating anti-allergy effect. These research results are believed to have the highest utility value as a functional cosmetic material in the future, and additional research is considered necessary.