The identification and correction of pseudohypercalcemia
This study confirmed that elevated globulin affects serum total calcium and offered the threshold of globulin ≥ 61 g/L in the differential diagnosis of peudohypercalcemia from hypercalcemia. The new formula based on albumin and globulin was developed, which was verified to be better than the traditional formula for correctly diagnosing hypercalcemia. In addition, we found that neither light chains nor heavy chains of monoclonal immunoglobulin alone can result in pseudohypercalcemia.
Authors
- Meilan Chen
- Beihui Huang (ORCID: https://orcid.org/0000-0003-2804-4913)
- Tao Yu (ORCID: https://orcid.org/0009-0003-8815-7407)
- Juan Li (ORCID: https://orcid.org/0000-0002-4603-1078)
- Jingli Gu (ORCID: https://orcid.org/0000-0001-5574-649X)
- Junru Liu (ORCID: https://orcid.org/0000-0001-6462-3547)
- Xiaozhe Li (ORCID: https://orcid.org/0009-0003-1903-3849)
Institutions
- Sun Yat-sen University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2024-10-31
- DOI
- https://doi.org/10.3389/fonc.2024.1441851
- Citations
- 1
- Primary Topic
- Bone health and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.28
Funders
- National Outstanding Youth Science Fund Project of National Natural Science Foundation of China