Exploring the key pathogenic mechanisms and potential intervention targets for Sophorae Flavescentis radix in managing bone metastasis of lung cancer based on network pharmacology and molecular docking techniques

Patients with lower <i>MMP1</i> levels had prolonged overall survival and may serve as a novel predictive biomarker for lung cancer. <i>Sophorae Flavescentis radix</i> appears to exert therapeutic effects on lung cancer bone metastasis by inhibiting <i>MMP1</i> expression and modulating the abnormal activation of the Wnt pathway. Our findings further extend the understanding of the pathogenic mechanisms and potential therapeutic interventions of <i>Sophorae Flavescentis radix</i> in lung cancer bone metastasis, providing a theoretical basis for clinical diagnosis and treatment research.