Performance of DNA methylation and blood-borne tumor indicators in detecting colorectal neoplasia and adenomas: a comparative study with the fecal occult blood test
For individual tests, FOBT and mSDC2 are relatively better indicators for detecting colorectal neoplasia compared to mSEPT9, CEA, CA125 and CA199. The combined form of mSEPT9 and mSDC2 to detect colorectal neoplasia has good predictive performance. However, none of these indicators demonstrated significant predictive power for detecting adenomas in our study.
Authors
- Chen-Li Zhang
- Bilian Yao (ORCID: https://orcid.org/0009-0009-1069-3991)
- Kaiyu Cai (ORCID: https://orcid.org/0009-0000-6718-9766)
- Ji Zhang (ORCID: https://orcid.org/0000-0001-7005-6980)
- Ying Chen
- Ming Chen (ORCID: https://orcid.org/0000-0001-5076-2917)
- Zhenzhen Wang (ORCID: https://orcid.org/0000-0003-3910-2517)
- Bin Xu (ORCID: https://orcid.org/0000-0001-8163-7895)
Institutions
- Shanghai Jiao Tong University (CN)
- Ruijin Hospital (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2024-10-31
- DOI
- https://doi.org/10.3389/fonc.2024.1373088
- Primary Topic
- Colorectal Cancer Screening and Detection
- Type
- article
- Field-Weighted Citation Impact
- 0.00