Exosomal AHSG in ovarian cancer ascites inhibits malignant progression of ovarian cancer by p53/FAK/Src signaling
The low expression of AHSG in exosomes derived from OC tissues and ascites is associated with metastatic progression in OC patients. Additionally, cancer-derived AHSG can be transported to OC cells via exosomes, where it inhibits OC migration <i>in vitro</i> and <i>in vivo</i> by regulating the p53/FAK/Src signaling pathway. The present study demonstrated that AHSG, derived from cancer cells, exerts a negative regulatory effect on OC cell motility, migration, and metastasis. These findings suggest that AHSG is a potential candidate for OC treatment.
Authors
- Bei Zhang (ORCID: https://orcid.org/0000-0003-1966-7676)
- Xueyan Zhou (ORCID: https://orcid.org/0000-0003-2821-1013)
- Yanyu Li (ORCID: https://orcid.org/0000-0003-1240-4785)
- Jiachen Ma (ORCID: https://orcid.org/0000-0002-0299-6003)
- Linna Chen
- Yongli Zhang (ORCID: https://orcid.org/0000-0001-9574-515X)
- Jingbo Zhang (ORCID: https://orcid.org/0000-0003-4816-7283)
- Guangyan Xie
- Xiaoli Guo (ORCID: https://orcid.org/0000-0003-4569-8708)
- Jiahao Xu (ORCID: https://orcid.org/0009-0007-4133-9384)
Institutions
- Xuzhou Medical College (CN)
- Affiliated Hospital of Xuzhou Medical College (CN)
Publication Details
- Journal
- Translational Cancer Research
- Published
- 2024-10-01
- DOI
- https://doi.org/10.21037/tcr-24-789
- Citations
- 3
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.70
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province