Weightlessness damaged the ultrastructure of knee cartilage and quadriceps muscle, aggravated the degeneration of cartilage
The weightless environment resulted in the damage of endoplasmic reticulum and mitochondria of cartilage, mitochondrial damage of quadriceps muscle, inactivation of muscle mitochondria (P=0.01), increased intra-articular inflammation (P=0.01), decreased elastic modulus and hardness (P=0.03), and damaged cartilage surface, which aggravated cartilage degeneration.
Authors
- Xu Cheng (ORCID: https://orcid.org/0000-0002-7523-3891)
- Fan Yang (ORCID: https://orcid.org/0000-0003-0563-3395)
- Hongjie Huang (ORCID: https://orcid.org/0000-0001-5300-4652)
- Xin Zhang (ORCID: https://orcid.org/0000-0001-9511-4737)
- Zhihua Zhang (ORCID: https://orcid.org/0000-0002-6449-4332)
- Jianquan Wang (ORCID: https://orcid.org/0000-0003-0504-7169)
- Zheng Zhou (ORCID: https://orcid.org/0000-0002-2444-0137)
- Kaiping Liu
Institutions
- Peking University (CN)
- Peking University Third Hospital (CN)
- China Astronaut Research and Training Center (CN)
Publication Details
- Journal
- Annals of Joint
- Published
- 2024-10-01
- DOI
- https://doi.org/10.21037/aoj-24-6
- Citations
- 1
- Primary Topic
- Neurogenetic and Muscular Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 0.44
Funders
- Peking University
- Peking University Third Hospital
- National Health Commission of the People's Republic of China