Screening of potential key pathogenic and intervention targets of low-grade glioma based on bioinformatics
For the prognosis of patients with LGG, the transcriptional activity of <i>SIGLEC8</i> is increased in LGG tissues and is an independent risk factor. Interference with <i>SIGLEC8</i> could promote tumor progression by regulating the JAK/STAT signaling pathway, indicating that <i>SIGLEC8</i> may function as a distinctive predictive biomarker for patients with LGG.
Authors
- Zhi-Song Jiu
- Wenlong Kong
- Xiaokang Yin (ORCID: https://orcid.org/0000-0003-3247-8730)
- Lizhi Yi
- Na Peng (ORCID: https://orcid.org/0000-0002-1832-9125)
- Zhengxian Huang
- Wei Chen (ORCID: https://orcid.org/0000-0002-4807-205X)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Longgang Central Hospital (CN)
Publication Details
- Journal
- Translational Cancer Research
- Published
- 2024-10-01
- DOI
- https://doi.org/10.21037/tcr-24-1662
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00