<i>PARP15</i> Is a Susceptibility Locus for Clarkson Disease (Monoclonal Gammopathy–Associated Systemic Capillary Leak Syndrome)
<i>PARP15</i> represents a previously unrecognized genetic susceptibility factor for MG-CLS. PARP15-mediated ADP ribosylation is an essential and genetically determined mechanism of the human vascular response to inflammation.
Authors
- Kirk M. Druey (ORCID: https://orcid.org/0000-0002-5834-6501)
- Ramaswamy Krishnan (ORCID: https://orcid.org/0000-0003-4994-0709)
- Ming Zhao (ORCID: https://orcid.org/0000-0002-5700-2950)
- Chandra C. Ghosh (ORCID: https://orcid.org/0009-0003-7471-0443)
- Samir M. Parikh (ORCID: https://orcid.org/0000-0002-1038-981X)
- Justin Lack (ORCID: https://orcid.org/0000-0003-0584-4010)
- Sundar Ganesan (ORCID: https://orcid.org/0000-0003-1132-2016)
- L. Renee Olano (ORCID: https://orcid.org/0000-0003-4862-3170)
- Abhishek Desai (ORCID: https://orcid.org/0000-0002-6770-4876)
- Niccole Schaible (ORCID: https://orcid.org/0000-0002-4765-5966)
- Ararat J. Ablooglu (ORCID: https://orcid.org/0009-0002-8692-4572)
- Xiuying Chen (ORCID: https://orcid.org/0000-0002-3950-755X)
- Eunice C. Chan (ORCID: https://orcid.org/0000-0003-0599-5898)
Institutions
- Beth Israel Deaconess Medical Center (US)
- National Institute of Allergy and Infectious Diseases (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2024-10-31
- DOI
- https://doi.org/10.1161/atvbaha.124.321522
- Citations
- 6
- Primary Topic
- PARP inhibition in cancer therapy
- Type
- article
- Field-Weighted Citation Impact
- 1.41
Funders
- U.S. Department of Health and Human Services
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases
- NHLBI Division of Intramural Research