Cell-autonomous IL6ST activation suppresses prostate cancer development via STAT3/ARF/p53-driven senescence and confers an immune-active tumor microenvironment
Our findings demonstrate a context-dependent role of IL6ST/STAT3 in carcinogenesis and a tumor-suppressive function in prostate cancer development by inducing senescence and immune cell attraction. We challenge the prevailing concept of blocking IL6ST/STAT3 signaling as a functional prostate cancer treatment and instead propose cell-autonomous IL6ST activation as a novel therapeutic strategy.
Authors
- Jan Pěnčík
- Saptaswa Dey (ORCID: https://orcid.org/0000-0001-7532-7858)
- Jessica Kalla (ORCID: https://orcid.org/0000-0002-0196-4659)
- Heidi A. Neubauer (ORCID: https://orcid.org/0000-0001-7372-7786)
- Karolína Trachtová
- Vojtěch Bystrý (ORCID: https://orcid.org/0000-0001-5278-0801)
- Nora S. Harbusch
- Jenny L. Persson (ORCID: https://orcid.org/0000-0001-7682-7678)
- Daniela Zwolanek (ORCID: https://orcid.org/0000-0001-5250-396X)
- Michaela Schlederer
- Felix Sternberg (ORCID: https://orcid.org/0000-0003-3487-362X)
- Christina Sternberg (ORCID: https://orcid.org/0000-0003-3756-0178)
- Monika Oberhuber (ORCID: https://orcid.org/0000-0002-5691-3605)
- Tanja Limberger (ORCID: https://orcid.org/0000-0002-1657-8670)
- Torben Redmer (ORCID: https://orcid.org/0000-0002-0050-9478)
- Robert Eferl (ORCID: https://orcid.org/0000-0002-6074-7144)
- Václav Hejret
- Lukas Kenner (ORCID: https://orcid.org/0000-0003-2184-1338)
- Stefan Stoiber (ORCID: https://orcid.org/0000-0003-3293-867X)
- Peter Wolf (ORCID: https://orcid.org/0000-0001-7777-9444)
- Jiaye Yang
- Šárka Pospı́šilová (ORCID: https://orcid.org/0000-0001-7136-2680)
- Gerda Egger (ORCID: https://orcid.org/0000-0003-2489-155X)
- Petra Kodajova (ORCID: https://orcid.org/0000-0003-2746-7631)
- Boris Tichý (ORCID: https://orcid.org/0000-0001-9252-7974)
- Martina Tomberger
- Sabine Lagger (ORCID: https://orcid.org/0000-0002-3032-9910)
- Stefan Rose‐John (ORCID: https://orcid.org/0000-0002-7519-3279)
- Simone Tangermann
- Martin Raigel
- Sandra Högler
- Roman Ziegler
- Desiree Lindner
Institutions
- University of Vienna (AT)
- Central European Institute of Technology (CZ)
- University of Veterinary Medicine Vienna (AT)
- Malmö University (SE)
- Medical University of Graz (AT)
- Charles University (CZ)
- Christian-Albrechts-Universität zu Kiel (DE)
- Central European Institute of Technology – Masaryk University (CZ)
- Comprehensive Cancer Center Vienna (AT)
- Christian Doppler Laboratory for Thermoelectricity (AT)
- BioTechMed-Graz (AT)
- Center For Biomarker Research In Medicine (AT)
- Medical University of Vienna (AT)
- Umeå University (SE)
Publication Details
- Journal
- Molecular Cancer
- Published
- 2024-10-31
- DOI
- https://doi.org/10.1186/s12943-024-02114-8
- Citations
- 10
- Primary Topic
- Cytokine Signaling Pathways and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 2.83