Overcoming multi-drug resistance in SCLC: a synergistic approach with venetoclax and hydroxychloroquine targeting the lncRNA LYPLAL1-DT/BCL2/BECN1 pathway
Our findings demonstrate that upregulation of LYPLAL1-DT sequesters apoptosis through the LYPLAL1-DT/miR-204-5p/BCL2 axis and promotes autophagy by facilitating the assembly of the BECN1/PtdIns3K complex, thereby mediating multi-drug resistance of SCLC. The triple combination of venetoclax, HCQ, in conjunction with cDDP, VP-16 or PTX overcomes refractory SCLC, shedding light on a potential therapeutic target for combating SCLC chemoresistance.
Authors
- Xiaoyan Du (ORCID: https://orcid.org/0000-0002-4030-7299)
- Jianyi Lv (ORCID: https://orcid.org/0000-0002-5288-5328)
- Qiuyu Zhang (ORCID: https://orcid.org/0009-0003-7880-9686)
- Zhihui Li (ORCID: https://orcid.org/0000-0002-2146-5857)
- Shuxin Li (ORCID: https://orcid.org/0009-0003-1477-4162)
- Li Deng (ORCID: https://orcid.org/0000-0002-9478-551X)
- Xueyun Huo (ORCID: https://orcid.org/0000-0002-1646-0963)
- Zhenwen Chen (ORCID: https://orcid.org/0000-0003-4678-3437)
- Xin Liu
- Changlong Li (ORCID: https://orcid.org/0000-0001-6832-785X)
- Jinghui Wang (ORCID: https://orcid.org/0000-0002-8462-3322)
- Meng Guo (ORCID: https://orcid.org/0000-0002-1482-1446)
- Jing Lu (ORCID: https://orcid.org/0009-0004-6370-2445)
- Hanping Shi
Institutions
- Capital Medical University (CN)
- Beijing Chest Hospital (CN)
- Beijing Shijitan Hospital (CN)
Publication Details
- Journal
- Molecular Cancer
- Published
- 2024-10-31
- DOI
- https://doi.org/10.1186/s12943-024-02145-1
- Citations
- 16
- Primary Topic
- Lung Cancer Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.52