Transriptome Analysis of Peripheral Blood Monocytes in Chronic Obstructive Pulmonary Disease Patients
The data obtained indicate inhibition of monocyte functional activity in COPD patients with a decrease in the ability to provide effective protection against microbial pathogens while weakening self-protection against reactive oxygen species. Upregulation of SERPINE1 and downregulation of TIMP3 may significantly contribute to airway remodeling and emphysema development in COPD.
Authors
- Д. Е. Наумов (ORCID: https://orcid.org/0000-0003-3921-8755)
- Y. G. Gorchakova
- E. G. Sheludko (ORCID: https://orcid.org/0000-0001-6622-5198)
- О. О. Котова (ORCID: https://orcid.org/0000-0002-1984-2596)
- D. A. Gassan (ORCID: https://orcid.org/0000-0003-3718-9962)
- I. Yu. Sugaylo
Institutions
- Far Eastern Scientific Centre of Physiology and Pathology of Respiration Russian Academy of Medical Sciences (RU)
Publication Details
- Journal
- Doklady Biochemistry and Biophysics
- Published
- 2024-10-31
- DOI
- https://doi.org/10.1134/s1607672924701199
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00