Hyperuricemia suppresses lumican, exacerbating adverse remodeling after myocardial infarction by promoting fibroblast phenotype transition
Hyperuricemia aggravates postinfarction cardiac remodeling by reducing lumican expression and promoting fibroblast phenotype transition. We highlight the clinical importance of lowering uric acid levels in hyperuricemia-related MI to prevent adverse ventricular remodeling.
Authors
- Jinghong Zhang (ORCID: https://orcid.org/0009-0000-3950-6752)
- Yanhua Tang (ORCID: https://orcid.org/0000-0003-0625-3423)
- Shuangjian Han
- Peiyuan Bai (ORCID: https://orcid.org/0000-0001-7812-2495)
- Ze‐Hao Zhuang (ORCID: https://orcid.org/0000-0001-7323-2900)
- Tingting Yu (ORCID: https://orcid.org/0000-0003-1694-7592)
- Ao Liu (ORCID: https://orcid.org/0000-0003-4833-5718)
- Heng Yang
- Hui Li (ORCID: https://orcid.org/0000-0002-6480-5866)
- Lu Tang (ORCID: https://orcid.org/0009-0006-0592-9179)
- Yiping Shi
Institutions
- Nanchang University (CN)
- Shanghai Jiao Tong University (CN)
- Peking University (CN)
- Fudan University (CN)
- Shanghai Chest Hospital (CN)
- Shanghai Mental Health Center (CN)
- Second Affiliated Hospital of Nanchang University (CN)
- Zhongshan Hospital (CN)
- Peking University Third Hospital (CN)
- Pudong New Area People's Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2024-10-31
- DOI
- https://doi.org/10.1186/s12967-024-05778-4
- Citations
- 5
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 1.70
Funders
- National Science Foundation
- National Natural Science Foundation of China
- Chinese Academy of Sciences
- China Postdoctoral Science Foundation
- Fudan University
- Natural Science Foundation of Jiangxi Province
- Key Research and Development Program of Jiangxi Province
- Postdoctoral Research Foundation of China