Isatin improves oligoasthenospermia caused by busulfan by regulating GSH/GPX4 axis to inhibit ferroptosis
ISA was found to effectively ameliorate oligoasthenospermia in mice, presenting a potential therapeutic option for patients with this condition.
Authors
- Jianwu Shi (ORCID: https://orcid.org/0000-0002-5429-9330)
- Jin Dong
- Fanshuo Zeng (ORCID: https://orcid.org/0000-0003-3649-579X)
- Chengniu Wang
- Taowen Ye (ORCID: https://orcid.org/0000-0002-4992-7566)
- Xiaorong Wang (ORCID: https://orcid.org/0000-0002-1912-3890)
- Lei Zhang (ORCID: https://orcid.org/0000-0001-5454-8758)
- Xiaoran Li (ORCID: https://orcid.org/0009-0003-6128-7412)
- Weizhen Wang (ORCID: https://orcid.org/0000-0001-7549-8374)
- Mingyu Jiang (ORCID: https://orcid.org/0000-0003-2059-4937)
Institutions
- Second Military Medical University (CN)
- Nantong University (CN)
- Nantong Maternity and Child Health Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-10-31
- DOI
- https://doi.org/10.3389/fphar.2024.1489956
- Citations
- 6
- Primary Topic
- Renal and related cancers
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Nantong University
- Natural Science Foundation of Nantong University