An Interesting Rare Case Report of Primary Amelanotic Melanoma With Distant Metastasis

Anorectal malignant melanoma (ARMM) is a rare and highly aggressive type of melanoma that originates in the anorectal area. It represents a small fraction of all melanoma cases and is often associated with poor prognosis due to its late presentation and challenging treatment options. Rectal malignant melanoma typically presents with symptoms such as rectal bleeding, pain, and obstructive symptoms. Diagnostic imaging and histopathological examination are crucial for accurate diagnosis, often requiring a combination of endoscopy, biopsy, and immunohistochemical staining. Treatment primarily involves surgical resection, though adjuvant therapies such as chemotherapy, immunotherapy, and radiation may be utilized depending on disease stage and metastasis. The prognosis remains guarded, with survival rates significantly lower compared to cutaneous melanoma, attributed to late-stage diagnosis and high likelihood of metastatic spread. Here we are reporting a case of ARMM presenting late with lung, skeletal, and liver metastasis.