Single and Combinatorial Effects of Metformin and Thymoquinone in Diffuse Large B Cell Lymphoma Cells
Diffuse large B cell lymphoma (DLBCL) is classified into Germinal Center B-cell (GCB) and activated B-cell (ABC) subgroups originating from different stages of lymphoid differentiation. Cell of origin dictates the behavior and therapeutic response of DLBCL. This study aimed to evaluate single and combinatorial effects of metformin and thymoquinone (TQ) in two DLBCL cell lines belonging to GCB and ABC subtypes. Metformin and TQ caused dose-dependent responses in both ABC and GCB DLBCL subtypes. Metformin had a greater impact on the ABC subtype while TQ demonstrated more pronounced effects on the GCB subtype. Synergistic effects were observed in the DHL4 (GCB subtype) but not in the HBL1 (ABC subtype) cell line. This is the first study to compare the effects of metformin and TQ in ABC versus GCB subtype of DLBCL. It brings valuable results that could be utilized in further research aimed at reshaping treatments for subtype-specific lymphomas.
Authors
- Abas Sezer (ORCID: https://orcid.org/0000-0002-8716-1768)
- Lejla Mahmutović (ORCID: https://orcid.org/0000-0002-7358-5009)
- Violeta Šoljić
- Katarina Vukojević (ORCID: https://orcid.org/0000-0003-2182-2890)
- Esma Bilajac (ORCID: https://orcid.org/0000-0001-5702-7990)
- Mirza Suljagić (ORCID: https://orcid.org/0000-0001-7533-9824)
- Una Glamočlija (ORCID: https://orcid.org/0000-0003-1206-6990)
Institutions
- University of Sarajevo (BA)
- University of Mostar (BA)
- International University of Sarajevo (BA)
- Institute of Metrology of Bosnia and Herzegovina (BA)
- Verlab (Bosnia and Herzegovina) (BA)
- University of Split (HR)
Publication Details
- Journal
- Chemistry & Biodiversity
- Published
- 2024-10-31
- DOI
- https://doi.org/10.1002/cbdv.202401533
- Primary Topic
- Chronic Lymphocytic Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00