Patient iPSC-derived neural progenitor cells display aberrant cell cycle control, p53, and DNA damage response protein expression in schizophrenia
Through targeted proteomics we demonstrate that SCZ NPC display coherent mechanistic alterations in regulation of DNA damage response, cell cycle control and p53 expression. These findings highlight the suitability of iPSC-based approaches for modeling psychiatric disorders and contribute to a better understanding of the disease mechanisms underlying SCZ, particularly during early development.
Authors
- Hansjürgen Volkmer (ORCID: https://orcid.org/0000-0002-3867-0603)
- Johanna Heider (ORCID: https://orcid.org/0009-0006-3741-7258)
- Katja Schenke‐Layland (ORCID: https://orcid.org/0000-0001-8066-5157)
- Richard Wüst
- Markus F. Templin (ORCID: https://orcid.org/0000-0002-6569-6489)
- Aaron Stahl (ORCID: https://orcid.org/0000-0003-3616-9564)
- Andreas J. Fallgatter (ORCID: https://orcid.org/0000-0001-7713-4259)
Institutions
- Natural and Medical Sciences Institute (DE)
- German Center for Infection Research (DE)
- University of Tübingen (DE)
Publication Details
- Journal
- BMC Psychiatry
- Published
- 2024-10-31
- DOI
- https://doi.org/10.1186/s12888-024-06127-x
- Citations
- 10
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 2.10
Funders
- Universitätsklinikum Tübingen