Different PSMA Radiopharmaceuticals: A Comparative Study of [18F]F-PSMA-1007, [18F]F-JK-PSMA-7, and [99mTc]Tc-PSMA-I&S in the Skeletal System
While radioligands behave similarly in bone regions, there are notable differences in SUV patterns, particularly for PSMA-1007, which showed higher bone uptake. Parotid gland uptake variability suggests a reconsideration of its suitability as a reference region, while the liver, spleen, and blood pool showed more consistent uptake. During comparison, the technetium-labeled SPECT ligand proved as similarly effective as the two PET ligands for diagnostic imaging.
Authors
- Gábor Sipka (ORCID: https://orcid.org/0000-0002-1259-0576)
- István Farkas (ORCID: https://orcid.org/0000-0002-6470-1880)
- Annamária Bakos
- Linda Varga
- Anikó Maráz (ORCID: https://orcid.org/0000-0002-2018-8413)
- Zsuzsanna Besenyi (ORCID: https://orcid.org/0000-0001-9115-9620)
- Mátyás Bukva (ORCID: https://orcid.org/0000-0002-5225-0285)
- Zsófia Sára Mikó
- Tamás Czékus
- László Varga
- Gyula Tóth
- László Pávics
- Kristóf Apró
- Barnabás Márk Révész
- Péter Gergő Tompa
Institutions
- University of Szeged (HU)
- Pozitron-Diagnosztika Kft (HU)
Publication Details
- Journal
- Pharmaceuticals
- Published
- 2024-10-31
- DOI
- https://doi.org/10.3390/ph17111458
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Szegedi Tudományegyetem
- National Research, Development and Innovation Office