Causal linkage of Graves’ disease with aging: Mendelian randomization analysis of telomere length and age-related phenotypes
GD accelerates the occurrence of age-related phenotypes including TL, senile cataracts, age-related hearing impairment, COPD, and sarcopenia. In contrast, there are no causal linkages between GD and facial aging, age-related macular degeneration, or Alzheimer's disease. Further experimental studies could be conducted to elucidate the mechanisms by which GD facilitates aging, which could help slow down the progress of aging.
Authors
- Yingshu Liu (ORCID: https://orcid.org/0000-0002-4671-1145)
- Jiahui Qin (ORCID: https://orcid.org/0000-0003-4021-994X)
- Xiaosong Qin
- Jin Zhang (ORCID: https://orcid.org/0000-0003-4495-4212)
- Jingwen Hu
- Haixia Bai (ORCID: https://orcid.org/0000-0002-7238-9831)
Institutions
- Shenyang 242 Hospital (CN)
- Shanghai Clinical Research Center (CN)
- The Sixth People's Hospital of Shenyang (CN)
- China Medical University (CN)
Publication Details
- Journal
- BMC Geriatrics
- Published
- 2024-10-31
- DOI
- https://doi.org/10.1186/s12877-024-05379-2
- Citations
- 5
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- China Medical University
- National Key Research and Development Program of China
- Shengjing Hospital