Defect-Engineered Coordination Compound Nanoparticles Based on Prussian Blue Analogues for Surface-Enhanced Raman Spectroscopy
Surface-enhanced Raman spectroscopy (SERS) is a powerful tool for label-free chemical analysis. The emergence of nonmetallic materials as SERS substrates, offering chemical signal enhancements, presents an exciting direction for achieving reproducible and biocompatible SERS, a challenge with traditional metallic substrates. Despite the potential, the realm of nonmetallic SERS substrates, particularly nanoparticles, remains largely untapped. Here, we present defect-engineered coordination compounds (DECCs) based on Prussian blue analogues (PBAs) as a class of nonmetallic nanoparticle-based SERS substrates. We demonstrate the utility and flexibility of the DECC template by incorporating various metal (M) elements into PBAs to synthesize nanoparticles that deliver substantial chemical mechanism (CM)-based enhancements to the Raman signal with a ∼ 10<sup>8</sup>-fold increase. The introduction of the M-PBA-based DECC nanoparticles as a class of SERS substrates represents a pioneering stride, enabling the straightforward and systematic exploration of a library of compounds for SERS-based analysis of a wide range of target molecules, especially biomolecules.
Authors
- J. Dong (ORCID: https://orcid.org/0009-0001-0779-0725)
- Xingxing Yu (ORCID: https://orcid.org/0009-0003-6366-5886)
- Keisuke Goda (ORCID: https://orcid.org/0000-0001-6302-6038)
- Walker Peterson (ORCID: https://orcid.org/0000-0002-6705-6039)
- Yunjie Deng (ORCID: https://orcid.org/0000-0003-4118-9068)
- Pablo Martínez Pancorbo (ORCID: https://orcid.org/0000-0002-8001-938X)
- Prabhat K. Dwivedi (ORCID: https://orcid.org/0000-0003-0248-1461)
- Abdullah N. Alodhayb (ORCID: https://orcid.org/0000-0003-0202-8712)
- Mitsuhiro Saito (ORCID: https://orcid.org/0000-0003-1602-0308)
- Naoki Kishimoto (ORCID: https://orcid.org/0000-0003-2988-456X)
- Ting‐Hui Xiao (ORCID: https://orcid.org/0000-0002-7339-152X)
- Machiko Marumi
- Yuichi Ikuhara (ORCID: https://orcid.org/0000-0003-3886-005X)
- Yasutaka Kitahama (ORCID: https://orcid.org/0000-0002-6447-2774)
- Xuke Tang
- Zhihao Gao (ORCID: https://orcid.org/0009-0003-4014-7605)
- Huanhuan Zhang (ORCID: https://orcid.org/0000-0002-2255-4261)
Institutions
- JEOL (Japan) (JP)
- University of California, Los Angeles (US)
- Tohoku University (JP)
- King Saud University (SA)
- Wuhan University (CN)
- Zhengzhou University (CN)
- National Institutes for Quantum Science and Technology (JP)
- Japan Fine Ceramics Center (JP)
- The University of Tokyo (JP)
- Indian Institute of Technology Kanpur (IN)
Publication Details
- Journal
- ACS Nano
- Published
- 2024-10-31
- DOI
- https://doi.org/10.1021/acsnano.4c06972
- Citations
- 18
- Primary Topic
- Gold and Silver Nanoparticles Synthesis and Applications
- Type
- article
- Field-Weighted Citation Impact
- 2.12
Funders
- Kanagawa Institute of Industrial Science and Technology
- Japan Science and Technology Corporation
- Ministry of Education, Culture, Sports, Science and Technology
- King Saud University
- University of Tokyo
- Murata Science Foundation
- Japan Society for the Promotion of Science