TM9SF1 expression correlates with autoimmune disease activity and regulates antibody production through mTOR-dependent autophagy
The primary finding was the identification of the molecular mechanism underlying autophagy regulation in B cells, in which Tm9sf1 knockout was found to modulate mTOR-dependent autophagy to block B cell differentiation into antibody-secreting plasma cells. It was also found that TM9SF1 expression level in PBMCs was an accurate indicator of disease activity in patients with RA and SLE, suggesting its clinical potential for monitoring disease activity in these patients.
Authors
- Zhen-Wang Zhao
- Anbing Zhang (ORCID: https://orcid.org/0000-0002-9266-655X)
- Fengsheng Cao
- Juan Xiao (ORCID: https://orcid.org/0000-0003-1064-0602)
- Ke Wang (ORCID: https://orcid.org/0000-0002-5305-6791)
- Hong Xiao (ORCID: https://orcid.org/0000-0003-1184-4279)
- Huabo Chen (ORCID: https://orcid.org/0000-0002-1276-9947)
- Jinsong Xiong (ORCID: https://orcid.org/0000-0002-0209-8596)
- Mingming Liu (ORCID: https://orcid.org/0000-0002-6750-5068)
- Fengqiao Zhou (ORCID: https://orcid.org/0000-0003-0362-7610)
- Lei Xiang
- Baoxian Gong
- Zean Yang
Institutions
- Hubei University of Arts and Science (CN)
- Xiangyang Central Hospital (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2024-10-31
- DOI
- https://doi.org/10.1186/s12916-024-03729-w
- Citations
- 5
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 1.93
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province
- Hubei University of Arts and Science
- Hubei University