Proteomic analysis of APOEε4 carriers implicates lipid metabolism, complement and lymphocyte signaling in cognitive resilience
We identified and replicated a plasma proteomic signature associated with cognitive resilience among APOEε4 carriers. These proteins implicate specific immune processes in the preservation of cognitive status despite elevated genetic risk for AD. Future studies in diverse cohorts will be needed to assess the generalizability of these results.
Authors
- Susan M. Resnick (ORCID: https://orcid.org/0000-0003-1115-7145)
- Aladdin H. Shadyab (ORCID: https://orcid.org/0000-0002-9693-0522)
- Ruin Moaddel (ORCID: https://orcid.org/0000-0002-6812-0127)
- Zhongsheng Peng (ORCID: https://orcid.org/0000-0001-7000-8647)
- Kathleen M. Hayden (ORCID: https://orcid.org/0000-0002-7745-3513)
- Ramon Casanova (ORCID: https://orcid.org/0000-0002-6934-5942)
- Luigi Ferrucci (ORCID: https://orcid.org/0000-0002-6273-1613)
- Michael R. Duggan (ORCID: https://orcid.org/0000-0002-1029-4423)
- Luke C. Pilling (ORCID: https://orcid.org/0000-0002-3332-8454)
- Qu Tian (ORCID: https://orcid.org/0000-0003-2706-1439)
- Stephen R. Rapp (ORCID: https://orcid.org/0000-0002-9766-3104)
- Abhay Moghekar (ORCID: https://orcid.org/0000-0001-9464-1551)
- Mark A. Espeland (ORCID: https://orcid.org/0000-0002-3711-1949)
- Madhav Thambisetty (ORCID: https://orcid.org/0000-0002-2200-2299)
- Keenan A. Walker (ORCID: https://orcid.org/0000-0002-5989-9853)
- Peter R. Rapp (ORCID: https://orcid.org/0000-0002-0983-3944)
- Shannon M. Drouin (ORCID: https://orcid.org/0000-0001-8767-5884)
- Dimitrios Kapogiannis
- Yang An
Institutions
- Johns Hopkins University (US)
- University of Exeter (GB)
- Johns Hopkins Medicine (US)
- University of California San Diego (US)
- Human Longevity (United States) (US)
- National Institute on Aging (US)
- Wake Forest University (US)
Publication Details
- Journal
- Molecular Neurodegeneration
- Published
- 2024-10-31
- DOI
- https://doi.org/10.1186/s13024-024-00772-2
- Citations
- 13
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.25
Funders
- U.S. Department of Health and Human Services
- Brigham and Women's Hospital
- Ohio State University
- Wake Forest University
- University of Pittsburgh
- University of Nevada, Reno
- MedStar Health Research Institute
- National Institutes of Health
- University at Buffalo
- National Institute on Aging
- National Heart, Lung, and Blood Institute