The Excellent Chemical Interaction Properties of Poloxamer and Pullulan with Alpha Mangostin on Amorphous Solid Dispersion System: Molecular Dynamics Simulation
The integration of molecular dynamics simulation into ASD development significantly accelerates the formulation process and provides critical insights into achieving a stable and effective AM dispersion. The AM-poloxamer complex, particularly at a 1:5 ratio with a 1 °C/ns cooling rate, offers the best potential for improving AM solubility and therapeutic efficacy.
Authors
- Yoga Windhu Wardhana (ORCID: https://orcid.org/0000-0002-4337-899X)
- Sandra Megantara (ORCID: https://orcid.org/0000-0003-4951-7740)
- Arif Budiman (ORCID: https://orcid.org/0000-0002-2028-3664)
- Agus Rusdin (ORCID: https://orcid.org/0000-0003-1243-7042)
- Taufik Muhammad Fakih (ORCID: https://orcid.org/0000-0001-7155-4412)
- Muchtaridi Muchtaridi (ORCID: https://orcid.org/0000-0002-6156-8025)
Institutions
- Bandung Islamic University (ID)
- Padjadjaran University (ID)
Publication Details
- Journal
- Polymers
- Published
- 2024-10-31
- DOI
- https://doi.org/10.3390/polym16213065
- Citations
- 4
- Primary Topic
- Polysaccharides Composition and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Universitas Padjadjaran
- Kementerian Pendidikan, Kebudayaan, Riset, dan Teknologi