A single risk assessment for the most common diseases of ageing, developed and validated on 10 cohort studies
The DemNCD is the first tool to predict both dementia and multiple cardio-metabolic diseases using comprehensive risk factors and provided similar predictive accuracy to existing risk tools. It has similar predictive accuracy as tools designed for single outcomes in this age-group. DemNCD has the potential to be used in community and clinical settings as it includes self-reported and routinely available clinical measures.
Authors
- Kim M. Kiely (ORCID: https://orcid.org/0000-0001-5876-3201)
- Craig S. Anderson (ORCID: https://orcid.org/0000-0002-7248-4863)
- Scherazad Kootar (ORCID: https://orcid.org/0000-0001-5496-3281)
- Henry Brodaty (ORCID: https://orcid.org/0000-0001-9487-6617)
- Jonathan E. Shaw (ORCID: https://orcid.org/0000-0002-6187-2203)
- Miia Kivipelto (ORCID: https://orcid.org/0000-0003-0992-3875)
- Michelle C. Carlson (ORCID: https://orcid.org/0000-0003-2465-7421)
- Nicola T. Lautenschlager (ORCID: https://orcid.org/0000-0003-4850-7794)
- Perminder Singh Sachdev (ORCID: https://orcid.org/0000-0002-9595-3220)
- Sebastian Köhler (ORCID: https://orcid.org/0000-0002-5316-1399)
- Martin P.J. van Boxtel (ORCID: https://orcid.org/0000-0002-3221-2150)
- Kaarin Jane Anstey (ORCID: https://orcid.org/0000-0002-9706-9316)
- Md Hamidul Huque (ORCID: https://orcid.org/0000-0002-5605-3801)
- Louisa Jorm (ORCID: https://orcid.org/0000-0003-0390-661X)
- Fiona E. Matthews (ORCID: https://orcid.org/0000-0002-1728-2388)
- Ruth Peters (ORCID: https://orcid.org/0000-0003-0148-3617)
- Rachel A. Whitmer (ORCID: https://orcid.org/0009-0006-9511-6138)
- Oscar L. López (ORCID: https://orcid.org/0000-0002-8546-8256)
- Annette L. Fitzpatrick
Institutions
- Mental Health Research Institute (AU)
- Baker Heart and Diabetes Institute (AU)
- Johns Hopkins University (US)
- The University of Melbourne (AU)
- University of Pittsburgh (US)
- University of Eastern Finland (FI)
- University of Hull (GB)
- University of Washington (US)
- University of Wollongong (AU)
- Karolinska Institutet (SE)
- UNSW Sydney (AU)
- Maastricht University (NL)
- Mental Health Australia (AU)
- The George Institute for Global Health (AU)
- Sydney Children’s Hospitals Network (AU)
- Imperial College London (GB)
- Neuroscience Research Australia (AU)
- University of California, Davis (US)
- Newcastle University (GB)
Publication Details
- Journal
- BMC Medicine
- Published
- 2024-10-31
- DOI
- https://doi.org/10.1186/s12916-024-03711-6
- Citations
- 6
- Primary Topic
- Frailty in Older Adults
- Type
- article
- Field-Weighted Citation Impact
- 2.07
Funders
- Alzheimer's Society
- Medical Research Council
- National Health and Medical Research Council
- National Institute on Aging
- National Heart, Lung, and Blood Institute
- National Institute of Neurological Disorders and Stroke
- SLAC National Accelerator Laboratory