SPARC activates p38γ signaling to promote PFKFB3 protein stabilization and contributes to keloid fibroblast glycolysis
Our findings indicated that SPARC could activate p38γ pathway to stabilize the expression of PFKFB3, and thus promote the glycolysis of KFs and the progression of keloid.
Authors
- Huaxia Chen (ORCID: https://orcid.org/0000-0001-6990-7602)
- Nan Lin (ORCID: https://orcid.org/0000-0003-2620-387X)
- Yanxin Liu (ORCID: https://orcid.org/0000-0001-5030-2435)
- Yining Liu (ORCID: https://orcid.org/0000-0001-8418-1360)
- Wei Zhang
- Zelei Yang
Institutions
- Qingdao University (CN)
- Shandong Provincial Hospital (CN)
- Affiliated Hospital of Qingdao University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Inflammation and Regeneration
- Published
- 2024-10-31
- DOI
- https://doi.org/10.1186/s41232-024-00357-y
- Citations
- 1
- Primary Topic
- Bone and Dental Protein Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.47