Ni-catalyzed reductive cyanation of alkenyl tosylates and triflates
Herein, we disclose the nickel-catalyzed reductive cyanation of alkenyl tosylates and triflates. Both cyclic and acyclic alkenyl nitriles are produced in moderate to good yield using 2-(4-methoxyphenyl)-2-methylmalononitrile (MeO-MPMN), a novel transnitrilation, or nitrile transfer, reagent. A robustness screen was undertaken to demonstrate the functional group tolerance of this method.
Authors
- Joshua M. Graham
- Sophie A. L. Rousseaux (ORCID: https://orcid.org/0000-0002-6505-5593)
Institutions
- University of Toronto (CA)
Publication Details
- Journal
- Chemical Communications
- Published
- 2024-10-31
- DOI
- https://doi.org/10.1039/d4cc04972a
- Citations
- 2
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.50
Funders
- Alfred P. Sloan Foundation
- Ontario Research Foundation
- Canada Foundation for Innovation
- Canada Research Chairs
- University of Toronto
- Natural Sciences and Engineering Research Council of Canada