Synthesis, crystal structure and Hirshfeld surface analysis of 2-{4-[(2-chlorophenyl)methyl]-3-methyl-6-oxopyridazin-1-yl}-<i>N</i>-phenylacetamide
In the title mol-ecule, C<sub>20</sub>H<sub>18</sub>ClN<sub>3</sub>O<sub>2</sub>, the 2-chloro-phenyl group is disordered to a small extent [occupancies 0.875 (2)/0.125 (2)]. The phenyl-acetamide moiety is nearly planar due to a weak, intra-molecular C-H⋯O hydrogen bond. In the crystal, N-H⋯O hydrogen bonds and π-stacking inter-actions between pyridazine and phenyl rings form helical chains of mol-ecules in the <i>b</i>-axis direction, which are linked by C-H⋯O hydrogen bonds and C-H⋯π(ring) inter-actions. A Hirshfeld surface analysis was performed, which showed that H⋯H, C⋯H/H⋯C and O⋯H/H⋯O inter-actions to dominate the inter-molecular contacts in the crystal.
Authors
- Youssef Ramli (ORCID: https://orcid.org/0000-0002-6885-5692)
- Hamza Assila (ORCID: https://orcid.org/0000-0001-8318-157X)
- Camille Kalonji Mubengayi
- Walid Guerrab (ORCID: https://orcid.org/0000-0001-7317-4771)
- Joel T. Mague (ORCID: https://orcid.org/0000-0003-3488-1945)
- Younes Zaoui (ORCID: https://orcid.org/0000-0003-1828-0402)
- Abdulsalam Alsubari
- M’hammed Ansar
Institutions
- Tulane University (US)
- Mohammed V University (MA)
- Institut Supérieur de Technique Médicale (CD)
Publication Details
- Journal
- Acta Crystallographica Section E Crystallographic Communications
- Published
- 2024-10-31
- DOI
- https://doi.org/10.1107/s2056989024010296
- Citations
- 1
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 0.25
Funders
- Tulane University